During a Mardi Gras parade in New Orleans, a young girl in a marching band is the latest victim to fall sick to a mysterious new virus - so sudden - it could only be named "XB". Dr. Clinton Earnshaw (Sam Groom) has been following the outbreak but has thus far only been able to diagnose it, when he is interrupted - and seemingly waylaid - by an apparent misfit, Jeff Adams (Tom Hallick). Adams' credentials say he's been sent by Washington to help, but with no medical background, Adams has little to recommend himself as being anything other than a drag on Earnshaw's limited time. (He sums himself up by describing his M.A. being in sociology from a "Cow College", and having dropped out of the space program.)
In 2013, a mysterious hole, called "Lost Hole", emerged from the sky, and along with it, came an enormous explosion that devastated the central Tokyo area and claimed the lives of many. Eighteen years later on April 28, 2031, in a newly rebuilt metropolis, a new event is about to occur, one that could change the fate of the world forever.